Savanthika william

William Shoki, drops tomorrow - I hope you will take a listen Thank you to all my guests William Shoki, Savanthika Pillay, Hatim.
Throughout the month of January, we released the 4 episodes of our podcast "Beyond a Declaration - What Rights can do"!
We will explore these questions and more with educator, Hatim Eltayeb and coach and therapist, Savanthika Pillay.

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The role of uromodulin in cardiovascular disease: a review

1 Introduction

In 1873, Italian physician Carlo Rovida made the initial observation of a protein present in human urine, forming tubular patterns, later identified as uromodulin(UMOD), also referred to as Tamm-Horsfall protein (THP). This protein is the most abundantly secreted protein in the urine of healthy individuals and is primarily synthesized by the epithelial cells lining the renal tubules. Initially termed “cilindrina” (1), it wasn't until 1950 that Igor Tamman and Frank Horsfall recognized its potential as a mucin in preventing viral blood clotting, leading to the adoption of the name “Tamm-Horsfall protein” (2, 3). Subsequent research by Muchmore and Decker in 1985 revealed its immunosuppressive properties in vitro against T cell proliferation and monocytotoxicity, prompting its renaming as uromodulin (4, 5). Further genomic analysis by Pennica et al. confirmed the equivalence of Tamm Horsfall protein and uromodulin (6). The elucidation of uromodulin's physiology, st

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Antipsychotic drugs and their possible cardiovascular adverse effects – literature review

1. Benistand P, Vorilhon P, Bouillon-Minois JB, Brousse G, Baker JS, Flaudias V, Mulliez A, Dutheil F. Effect of the COVID-19 pandemic on the psychotropic drug consumption. Frontiers in Psychiatry. 2022 Dec 15;13:1020023.

2. Ministerstwo Zdrowia [Internet]. [cited 2024 Aug 08];Available from: https://archiwum.mz.gov.pl/zdrowie-i-profilaktyka/ promoc ja-zdrowia/jakdzialazdrowyczlowiek/zdrowie¬psychiczne-polakow-w-roli-glownej-mozg/

3. Solmi M, Radua J, Olivola M, Croce E, Soardo L, Salazar de Pablo G, Il Shin J, Kirkbride JB, Jones P, Kim JH, Kim JY. Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies. Molecular psychiatry. 2022 Jan;27(1):281-95.

4. Ayano G. Schizophrenia: a concise overview of etiology, epidemiology diagnosis and management: review of literatures. J Schizophrenia Res. 2016 Aug;3(2):2-7.

5. Chen Q, Huang S, Xu H, Peng J, Wang P, Li S, Zhao J, Shi X, Zhang W, Shi L, Peng Y. The burden of mental disorders in Asian co

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Abstract

Precapillary pulmonary hypertension (PH) is a significant complication of systemic sclerosis (SSc). It represents one of the leading causes of morbidity and mortality, correlating with a significantly dismal prognosis and quality of life. Despite advancements in the management of patients with pulmonary arterial hypertension associated with SSc (SSc-PAH), no significant improvement has been reported in survival of patients with precapillary SSc-PH associated with extensive lung parenchyma disease. International expert consensus and guidelines for the management of PH recommend annual screening of SSc patients for early detection of pre-capillary PH. The implementation of screening algorithms capable of identifying patients with a high likelihood of developing PH could help limit unnecessary right-heart catheterization procedures and prevent significant delay in diagnosis. Furthermore, early initiation of up-front combination targeted therapy in patients with PAH has shown increase in survival rates, indicating that timely and aggressive medical therapy is key for stabili